Supramolecular chemistry at interfaces Host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica

Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery.

Title:	Supramolecular chemistry at interfaces Host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica
Authors:	Tran, T.V. Vo, U.V. Pham, D.Y., (...) Thu, L.V. Nguyen, D.H.
Keywords:	5-fluorouracil, cancer therapy, drug delivery systems, porous nanosilica
Issue Date:	2016
Publisher:	Walter de Gruyter GmbH
Citation:	Scopus
Abstract:	Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (PNSC@APEG) was successfully prepared with spherical shape and diameter around 50 nm, determined by transmission electron microscopy (TEM). In addition, 5-FU was efficiently trapped in PNSC@APEG particles, which were around 63.4%±3.8% and was slowly released up to 3 days in phosphate buffer saline (PBS). Furthermore, the cell proliferation kit I (MTT) assay data showed that PNSC@APEG was a biocompatible nanocarrier. These results indicated that PNSC@APEG nanoparticles have a great potential as novel carriers for anticancer drug delivery.
Description:	Green Processing and Synthesis Volume 5, Issue 6, 1 December 2016, Pages 521-528
URI:	https://www.degruyter.com/view/j/gps.2016.5.issue-6/gps-2016-0049/gps-2016-0049.xml http://repository.vnu.edu.vn/handle/VNU_123/34061
ISSN:	21919542
Appears in Collections:	Bài báo của ĐHQGHN trong Scopus