Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazones
Title: Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazones Authors: Thanh, N.D. Giang, N.T.K. Quyen, T.H. Huong, D.T. Toan, V.N. Keywords: Antibacterial;Antifungal;Antioxidant activity;Cytotoxic effects;D-glucose;Isatins;Methicillin-resistant Staphylococcus aureus;Microwave-assisted synthesis;Thiosemicarbazones Issue Date: 2016 Publisher: Elsevier Masson SAS Citation: Scopus Abstract: Some new isatin N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazones 4a-t with different substituents at 1-, 5- and 7-positions of isatin ring have been synthesized by reaction of N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazide 2 with corresponding isatins 3a-t. Compounds 4a-t were evaluated in vivo for antioxidant activity and in vitro for anti-microorganism activities. ...